Trav. Agency for Toxic Substances and Disease Registry NIST subscription sites provide data under the How can trichlorobenzenes affect children? Browse 1,2,4-Trichlorobenzene and related products . The following list includes links related to the selected substance. The standard enthalpies of formation of mono-1,2,4- and 1,3,5-tri-, and 1,2,3,4- and 1,2,3,5-tetrachlorobenzenes, [all data], Jondorf and Williams, 1958 CAS 120-82-1, chemical formula CH-1,2,4- (Cl). H302: Harmful if swallowed. 1,2,4-Trichlorobenzene | C6H3Cl3 - PubChem Apologies, we are having some trouble retrieving data from our servers. 1,2,4-Trichlorobenzene, NIOSH: Pocket Guide to Chemical Hazards - CHEMICAL NAME : Benzene, 1,2,4-trichloro- CAS REGISTRY NUMBER : 120-82-1 BEILSTEIN REFERENCE NO. Eng. Long term administration of 1,2,4-trichlorobenzene to rats did not affect their capacity to have normal offspring. Toxicological Profile for Trichlorobenzenes, Agency for Toxic Substances and Disease Registry, U.S. Department of Health & Human Services. Dreisbach, R.R., It's important you understand this information because this substance may harm you. 1,2,4-Trifluorobenzene | C6H3F3 - PubChem compound Summary 1,2,4-Trifluorobenzene Cite Download Contents 1 Structures 2 Names and Identifiers 3 Chemical and Physical Properties 4 Spectral Information 5 Related Records 6 Chemical Vendors 7 Safety and Hazards 8 Literature 9 Patents 10 Classification 11 Information Sources 1 Structures Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 118 K) Not assessed under the IRIS Program. Sears, G.W. such sites. Data compilation copyright Photoelectron spectra of and Ab initio calculations on chlorobenzenes. Colorless liquid or crystalline solid (below 63F) with an aromatic odor. Wilhelm, E.; Inglese, A.; Quint, J.R.; Grolier, J.-P.E., Wilhelm, E.; Lainez, A.; Roux, A.H.; Grolier, J.-P.E., [ 1] Application 1,2,4-Trichlorobenzene may be used as a solvent to prepare: dimethylketene -lactone dimer from tetramethyl-1,3-cyclobutanedione [ 2] Based on data from 279. Fast, safe transfer of plates to isolator. [all data], Dreisbach, 1955 It is also frequently used to produce dyes and textiles. [all data], Jones, 1960 2021 by the U.S. Secretary of Commerce All sampling instructions above are recommended guidelines for OSHA Compliance Safety and Health Officers (CSHOs), please see the corresponding OSHA method reference for complete details. J. Chem. (1) The vapor pressure for 1,2,4-trichlorobenzene is 0.29 mm Hg at 25 C, and its log octanol/water partition There are no studies of children exposed to trichlorobenzenes. Select a region with no data or The quantity field is empty. D0-(]PlAm*R5&{b>#7b]'Ddm\Bj. Galat, A., ; Nibbering, N.M.M., Avoid areas near facilities that manufacture and use trichlorobenzenes and other chlorinated substances or hazardous waste sites that contain these substances. The product quantity has been adjusted. [4] There is no regulated occupational exposure limit for chemical exposure, but the National Institute for Occupational Safety and Health recommends no greater exposure than 5 ppm, over an 8-hour workday. Synonyms: 1,2,4-Trichlorobenzene. The isomers may also have different chemical and toxicological properties.[2][3]. The EPA has determined that lifetime exposure to 1,2,4- or 1,3,5-trichlorobenzene in drinking water at concentrations up to 0.07 and 0.04 mg/L, respectively, is not expected to cause any adverse effects. If required, we will contact you for this information once your order is placed. (5) 1,2,4-Trichlorobenzene occurs as a colorless liquid that is insoluble in water. View image of digitized J. Chem. For the most part, studies in animals given trichlorobenzenes during pregnancy have not found adverse effects in the pups at birth or during the growing period. P264: Wash skin thoroughly after handling. InChI=1/C6H3Cl3/c7-4-1-2-5(8)6(9)3-4/h1-3H<, Except where otherwise noted, data are given for materials in their, National Institute for Occupational Safety and Health, Ullmann's Encyclopedia of Industrial Chemistry, CDC - NIOSH Pocket Guide to Chemical Hazards, https://en.wikipedia.org/w/index.php?title=1,2,4-Trichlorobenzene&oldid=1119441075, This page was last edited on 1 November 2022, at 16:19. Benzene, 1,2,4-trichloro- Formula: C 6 H 3 Cl 3 Molecular weight: 181.447 IUPAC Standard InChI: InChI=1S/C6H3Cl3/c7-4-1-2-5 (8)6 (9)3-4/h1-3H IUPAC Standard InChIKey: PBKONEOXTCPAFI-UHFFFAOYSA-N CAS Registry Number: 120-82-1 Chemical structure: This structure is also available as a 2d Mol file or as a computed 3d SD file and Informatics, NIST / TRC Web Thermo Tables, professional edition (thermophysical and thermochemical data), Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein. Here, the parent ring is styrene a benzene ring is attached to the vinyl unsaturated protons, and the chloro group is present . The chemical formula for 1,2,4-trichlorobenzene is C 6 H 3 Cl 3, and its molecular weight is 181.46 g/mol. Phone: 1-800-CDC-INFO 888-232-6348 (TTY) Merck KGaA, Darmstadt, Germany, 2014. The isomers differ slightly from each other in their chemical structure. Please see the following for information about The purpose of the fee is to recover costs associated the 1,2,3-, 1,2,4-, and 1,3,5-Trichlorobenzene have been found in at least 31, 187, and 4 of the 1,699 National Priorities List sites identified by the Environmental Protection Agency (EPA), respectively. Our portfolio of innovative products, services and solutions. The reaction is as follows: HeH + He + H +. If you have questions or concerns, please contact your community or state health or environmental quality department or: For more information, contact: Pays-Bas, 1932, 51, 98-113. The general population may be exposed to trichlorobenzenes by inhaling air and through the ingestion of food and drinking water. Structure, properties, spectra, suppliers and links for: 1,1'-[(4-{2-[4-(Dimethyliminio)-2,5-cyclohexadien-1-ylidene]ethylidene}-4H-pyran-2,6-diyl)di-2,1. These cookies may also be used for advertising purposes by these third parties. Stable. (TRC) data available from this site, much more physical Find the products and services for your process. SRD 103a Thermo Data Engine (TDE) for pure compounds. also available. CAS 120-82-1, chemical formula CH-1,2,4- (Cl). H302: Harmful if swallowed. There is almost no information about health effects of trichlorobenzenes in humans. Medium. Increased adrenal weights; vacuolization of zona fasciculata in the cortex. 1,2,4-Trichlorobenzene. the library and Particulate-phase 1,2,4-tribromo-3,5,6-trichlorobenzene will be removed from the atmosphere by wet and dry deposition. It appears that your browser has JavaScript disabled. [all data], Weast and Grasselli, 1989 Buying Leads | * Chim. Data Program, but require an annual fee to access. in these sites and their terms of usage. 6.1C Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects, harmful, irritant, dangerous for the environment, UN 2321 , 6.1, III, Marine Pollutant: P, Segregation Group: 10 (Liquid halogenated hydrocarbons). Trichlorobenzenes, tetrachlorobenzenes, and pentachlorobenzene, ALS - Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein Good cell culture practices start with proven products like Stericup and Millex filters. Data, 1960, 5, 2, 196-200, https://doi.org/10.1021/je60006a019 Chem. Last Updated: 05/01/1992. Acta, 1986, 105, 101-110. Institute of Standards and Technology, nor is it intended to imply Reference Dose for Oral Exposure (RfD) (PDF) (14 pp, 118 K) J. Chem. People who manufacture or work with trichlorobenzenes can be exposed to them. kH = Henry's law constant for solubility in water at 298.15 K (mol/(kg*bar)) Biochem. shall not be liable for any damage that may result from Please enter a quantity of 1 or more to add items to your cart. Volatilization from moist soil surfaces may be an important fate process based upon an estimated Henry's Law . Even though the forms have the same molecular weight and molecular formulae, they are structurally different by the positions of the chlorine atoms attached to the benzene ring. Aside from its use as a solvent, this compound is a useful precursor to dye and pesticides. Trichlorobenzenes evaporate from soils and are slowly broken down by microorganisms in soil and sediment. the 1,2,3-Trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, while 1,2,4 trichlorobenzene is a colorless liquid. The EPA has stated that 1,2,4-trichlorobenzene is not classifiable as to human carcinogenicity. Synthesis Reference(s): Journal of the American Chemical Society, 74, p. 3890, 1952 DOI: 10.1021/ja01135a052: Physical Properties for CAS 120-82-1: Trichlorobenzenes can be measured in blood and body fat, but the tests used are not routinely available in the doctor's office. https://en.wikipedia.org/w/index.php?title=Trichlorobenzene&oldid=1074841239, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 2 March 2022, at 13:41. Russ. Thermochim. There is virtually no information regarding health effects of trichlorobenzenes in humans. The acidity of chloro-substituted benzenes: A comparison of gas phase, ab initio, and kinetic data, Sublimation Pressure Data for Organic Compounds., TRC - Thermodynamics Research Center, NIST Boulder Laboratories, Chris Muzny director Catalogs and product finders. . HeH + contains all paired electrons. Journals | Vapor Pressures of the Isomeric Trichlorobenzenes in the Low Pressure Region, Am. reaction search pages in place of the enumerated reaction In addition to the Thermodynamics Research Center All rights reserved. (1) The vapor pressure for 1,2,4-trichlorobenzene . The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. 23(11) , 1806-14, (2010). 1,2,4-Trichlorobenzene MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. P = vapor pressure (bar) shall not be liable for any damage that may result from Reference Concentration for Inhalation Exposure (RfC) (PDF) (14 pp, 118 K) Technology, Office of Data 2,3,5-Trichlorobenzene-1,4-diol | C6H3Cl3O2 - PubChem compound Summary 2,3,5-Trichlorobenzene-1,4-diol Cite Download Contents 1 Structures 2 Names and Identifiers 3 Chemical and Physical Properties 4 Spectral Information 5 Related Records 6 Chemical Vendors 7 Pharmacology and Biochemistry 8 Literature 9 Patents 10 Taxonomy 11 Classification The isomers may also have different chemical and . 1,2,4-trichlorobenzene The TCB/toluene solution of La@C82 (C2v) and an excess amount of Ad in a seal tube was irradiated with a high-pressure mercury lamp, producing the monoadduct in 80% yield. These clinics specialize in recognizing, evaluating, and treating illnesses resulting from exposure to hazardous substances. P264: Wash skin thoroughly after handling. Contact Us to ask a question, provide feedback, or report a problem. View plot Your institution may already be a subscriber. HeH + has bond order 1.. . van de Lande, L.M.F., Biologically Active Compounds | Hydrophobic and hydrophilic membranes for filtration and venting applications. CAS: 120-82-1 MDL: MFCD00000547 EINECS: 204-428- . The . However, a study in rats given 1,2,4- or 1,3,5-trichlorobenzene found lesions in the eyes of the pups. #=0!w}S&!T7U/9s$5U]O~K%~ed>7ueY?*us6/Wn]/LfSG{q&^{Wz;Ec' SUvE9d"Mxx*?~:YfDK(@+hwh'3hbc^.P)d!9(@ !pqp888 j"Si)rZr Synonyms. HTML 5 canvas support. L'tude de Tunnel Dmagntiseurs Le march comprend des statistiques sur la taille du march, les parts rgionales et les parts des concurrents, les segments profonds, les tendances du march, les opportunits et d'autres informations pertinentes. Is there a medical test to show whether I've been exposed to trichlorobenzenes? Rohc, Vladislav; Ruzicka, Vlastimil; Ruzicka, Kvetoslav; Aim, Karel, What happens to trichlorobenzenes when it enters the environment? It is a colorless liquid used as a solvent for a variety of compounds and materials. Depending on the conditions and additives (e.g., sulfur), it can be the main product from the chlorination of benzene. There are no studies of cancer in people exposed to trichlorobenzenes. ), 1985, 59, 179-181. Follow the links above to find out more about the data [all data], Rohc, Ruzicka, et al., 1999 Substance Details Internal Tracking Number: 31435 Substance Type: Chemical Substance Systematic Name: Benzene, 1,2,4-trichloro- CAS Number: 120-82-1 EPA Registry Name: 1,2,4-Trichlorobenzene Molecular Weight: 181.45 Molecular Formula: C6H3Cl3 Additional Metadata Go To: Top, Gas phase thermochemistry data, Condensed phase thermochemistry data, Phase change data, Reaction thermochemistry data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, kH(T) = kH exp(d(ln(kH))/d(1/T) ((1/T) - 1/(298.15 K))) The preparation method of any one of Claims 1 to 9, wherein, the first solvent is selected from one or a mixture of two or more of 1,2,4-trichlorobenzene, o-dichlorobenzene, chlorobenzene, anisole, toluene, nitrobenzene, isopropyl alcohol, Chem. NOAA: CAMEO Chemicals - Incompatible with strong oxidizing agents. Physical Properties of Chemical Compounds, Advances in Chemistry Series No. in these sites and their terms of usage. Petit, J.C.; TerMinassian, L., How might I be exposed to trichlorobenzenes? This fact sheet is one in a series of summaries about hazardous substances and their health effects. However, NIST makes no warranties to that effect, and NIST The product He + H + is stable because in this both the electrons are close to nucleus of hydrogen and helium cation. Last Updated: 06/01/1989, Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 118 K), Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 118 K). Trichlorobenzenes have been used as solvents. CAS 120-82-1, chemical formula CH-1,2,4-(Cl). P264: Wash skin thoroughly after handling. Polymeric Microspheres and Magnetic Beads, Novabiochem Peptide and DNA Synthesis Reagents, Analytics and Sample Preparation Services, BioReliance Cell and Gene Therapy Testing Services, Calibration, Verification and Suitability Testing, Process Solutions: Portfolio Announcements, Organic Synthesis Building Blocks and Reagents for Pharma. Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter, 2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%. - 298. 1,2,3-Trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, but 1,2,4-trichlorobenzene is a colorless oil. HU0~]$'RWS`HlE*'G8 . Select a region with data to zoom. and Informatics, NIST / TRC Web Thermo Tables, professional edition (thermophysical and thermochemical data). Ind. Mice given 1,2,4-trichlorobenzene in the food for 2 years developed cancer of the liver. This fact sheet answers the most frequently asked health questions (FAQs) about trichlorobenzenes. intended to imply recommendation or endorsement by the National Imaging flow cytometry makes it possible. Chem. errors or omissions in the Database. 1,2,4-trichlorobenzene EC Number: 204-428- EC Name: 1,2,4-trichlorobenzene CAS Number: 120-82-1 Molecular formula: C6H3Cl3 IUPAC Name: 1,2,4-trichlorobenzene. such sites. Email: Contact CDC-INFO. 1,2,4-Trichlorobenzene is a highly chlorinated aromatic solvent. United States Environmental Protection Agency. Recently, polymerization of structure 102 carried out in 1,2-dichlorobenzene at 25 . Combustible. endstream endobj 26 0 obj <>stream [all data], Spieksma, Luijk, et al., 1994 Data compiled by: Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein, Go To: Top, Gas phase thermochemistry data, Phase change data, Reaction thermochemistry data, Henry's Law data, Gas phase ion energetics data, IR Spectrum, Mass spectrum (electron ionization), UV/Visible spectrum, References, Notes, Data compiled as indicated in comments: On this Wikipedia the language links are at the top of the page across from the article title. This table shows how each list refers to the substance. A-006. ; Coefficents calculated by NIST from author's data. What Generation is Your Sterility Testing Pump? Trichlorobenzenes have been identified in a variety of food items including vegetables, milk, eggs/meat, and oils produced from various nuts and seeds. H315: Causes skin irritation. According to the given name benzene is tri-substituted with Bromo, chloro, and a methyl group at positions 4,1 and 2 so the structure is: Compound F is m-chloro styrene. H410: Very toxic to aquatic life with long lasting effects. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Th Huaxue Xuebao, 1987, 45, 1184-1187. This may be a synopsis of the full weight-of-evidence narrative. J. Database and to verify that the data contained therein have Stull, Daniel R., with the development of data collections included in Use or mention of technologies or programs in this web site is not Copyright for NIST Standard Reference Data is governed by Please enable JavaScript and reload this page. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. Shanghai Jizhi Biochemical Technology Co., Ltd, 1,2,4-Trichlorobenzene suppliers in China, 5-(4-Chlorophenoxy)-1,2,4-trichlorobenzene, 5-((4-Chlorophenyl)sulfinyl)-1,2,4-trichlorobenzene, 1,2,4-tris(methylthio)-3,5,6-trichlorobenzene. 1,2,4-Trichlorobenzene is produced in large 15, Am. Knowledgebase & FAQs; Advanced Products; Applications & Protocols Life Science Research Solutions, Products, and Resources Chromatography and Mass Spectrometry . Huaxue Xuebao, 1987, 45, 1184. III. ALS - Hussein Y. Afeefy, Joel F. Liebman, and Stephen E. Stein, log10(P) = A (B / (T + C)) Even though the forms have the same molecular weight and molecular formulae, they are structurally different by the positions of the chlorine atoms attached to the benzene ring. Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. 1,2,4-Trichlorobenzene for synthesis. Detecting breakdown products of trichlorobenzenes may mean that you were exposed to trichlorobenzenes or that you were exposed to other chemicals that produce the same breakdown products. Articles of 1,2,4-Trichlorobenzene are included as well. The effects of exposure to any hazardous substance depend on the dose, the duration, how you are exposed, personal traits and habits, and whether other chemicals are present. Trichlorobenzenes are volatile and preferentially enter the air when released to the environment. Synonyms. It is a derivative of benzene with three chloride substituents. 1,2,3-Trichlorobenzene and 1,3,5-trichlorobenzene are colorless solids, but 1,2,4-trichlorobenzene is a colorless oil. Purchase 120-82-1 Certified Reference Standards from AccuStandard. It is also the main product from the dehydrochlorination of hexachlorocyclohexane.[3]. CRC Handbook of Data on Organic Compounds, 2nd Editon, Weast,R.C and Grasselli, J.G., ed(s)., CRC Press, Inc., Boca Raton, FL, 1989, 1. Recommended vapour and sublimation pressures and related thermal data for chlorobenzenes, For more information, call the CDC Information Center at 1-800-232-4636. 1,2,4-Trichlorobenzene is an organochlorine compound, one of three isomers of trichlorobenzene. other in their chemical structure. Trichlorobenzenes tend to evaporate from water, but can also bind to suspended solids and sediment in water. [all data], Platonov and Simulin, 1985 The following components were used in generating the plot: Additonal code used was developed at NIST: Eur. Yan, H.; Gu, J.; An, X.; Hu, R.-H.,
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